Accession Number:

ADA002623

Title:

Chelated Trace Metals in Wound Repair.

Descriptive Note:

Final rept. 1 Jun 68-31 May 74,

Corporate Author:

GEORGETOWN UNIV WASHINGTON D C DEPT OF BIOCHEMISTRY

Personal Author(s):

• Rubin,Martin I.

Report Date:

1974-07-15

Pagination or Media Count:

77.0

Abstract:

Healing of a standardized bone injury in guinea pigs has been studied following treatment with zinc compounds. Zinc uptake, isotopic zinc uptake, histology of the regenerative area and growth response of the animals were used as parameters of response. Zinc chelates able to form bidentate structures carrying an anionic charge were more effective than zinc sulfate and untreated controls in speeding early healing. Ultracentrifugal studies have established the formation of a ternary complex in plasma between albumin zinc and effective wound healing ligands. Histidine but not other amino acids is capable of the same molecular combination. The data provide a reasonable molecular basis for explanation of the in vivo results.

Descriptors:

• *ZINC
• *WOUNDS AND INJURIES
• *HEALING
• METALS
• EXPERIMENTAL DATA
• THERAPY
• MEDICAL RESEARCH
• HISTOLOGY
• TRACE ELEMENTS
• GROWTH(PHYSIOLOGY)
• GUINEA PIGS
• BONE FRACTURES

Subject Categories:

• Biochemistry
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE