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Blood Substitutes: Oxygen Transport of Colloidal Fluorocarbon Suspensions in Asanguineous Rabbits.
Final rept. 1 Nov 69-31 Oct 73,
MIAMI UNIV FLA SCHOOL OF MEDICINE
Pagination or Media Count:
Fine emulsions of fluorocarbon fluids can substitute for the gas-exchange function of red cells in perfused organs, however their effectiveness in the intact organism is not yet known. The red cell volume of control rabbits was exchanged with a plasma expander until a hematocrit of 3 was reached. In test animals 20 of a colloidal fluorocarbon suspension was added to the plasma expander. The prolongation of survival time from about 30 min. of the asanguineous control animals to about 120 min. of the fluorocarbon suspension containing animals was due to a 20 increase in cardiac output and an 86 increase in arterial oxygen content. The longer survival rate of oxygen breathing rabbits above a hematocrit of 10, whose red cells have been replaced with a colloidal fluorocarbon suspension is mainly due to its role as an efficient volume expander and only secondarily as an oxygen carrier.
APPROVED FOR PUBLIC RELEASE