Phenomenon of Refractivity in an Antiviral Action of Synthetic Polynucleotides
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK United States
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Synthetic RNA including complexes of polyinosine and polycytidylic acids polyI C, polyguanylic and polycytidylic acids polyG C and others are capable of inducing both in tissue culture and the organisms of laboratory animals two apparently interrelated phenomena that is the development of the antiviral state and induction of interferon formation. An original property of the inductors of interferon formation was discovered and studied to a great extent, to determine development both in vivo and in vitro of the refractivity to repeated stimulation of interferon development. An investigation of the phenomenon resulted in the problem of developing optimum systems for introducing these antiviral preparations as well as a search for methods of overcoming this problem. However, subsequent experiments demonstrated that the antiviral effect develops also at the moment of the condition of refractivity to interferon induction and it is possible that these two phenomena have little in common.