Accession Number:

ADA001850

Title:

Experimental Sensitization of Guinea Pigs with Neoarsphenamine,

Descriptive Note:

Corporate Author:

FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s):

Report Date:

1974-11-13

Pagination or Media Count:

19.0

Abstract:

Increased sensitivity of guinea pigs to neoarsphenamine developed 3-4 days after the intradermal administration of 150 micrograms neoarsphenamine and testing with the same compound on the 21st day. The formation of crossed allergic skin reactions with neoarsphenamine NOVAR and with related compounds - with salvarsan, osarsol and myarsenol is possible. The intravenous administration of 15 micrograms of neoarspehnamine NOVAR before testing selectively delayed the development of contact allergic reactions by more than 144 hours. The intraperitoneal administration of 20 micrograms of neoarsphenamine NOVAR in a solution of TWEEN-80 three weeks before sensitization delayed the development of contact allergic skin reactions for a period of up to 140 days from the beginning of sensitization.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE