Accession Number:

ADA001502

Title:

Catalysis by Acetylcholinesterase. Substrate-Mediated Perturbations.

Descriptive Note:

Technical rept. Mar-Oct 71,

Corporate Author:

EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD

Report Date:

1974-10-01

Pagination or Media Count:

18.0

Abstract:

The characteristics of the inhibition of acetylcholinesterase by hexamethylenebisdimethyl3-phthalimidopropylammonium bromide PTP are both qualitatively and quantitatively different when examined in the presence of the substrates acetylcholine ACh and phenyl acetate PA. Results are interpreted in terms of the Rosenberry and Bernhard 1972 model for acetylcholinesterase catalysis, which involves specific regulatory and inhibitory sites on the enzyme, and offer additional support for this model. Perturbation of the enzyme via such regulatory sites may provide new approaches to prophylaxis and therapy for poisoning by anticholinesterase compounds.

Subject Categories:

  • Biochemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE