Catalysis by Acetylcholinesterase. Substrate-Mediated Perturbations.
Technical rept. Mar-Oct 71,
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
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The characteristics of the inhibition of acetylcholinesterase by hexamethylenebisdimethyl3-phthalimidopropylammonium bromide PTP are both qualitatively and quantitatively different when examined in the presence of the substrates acetylcholine ACh and phenyl acetate PA. Results are interpreted in terms of the Rosenberry and Bernhard 1972 model for acetylcholinesterase catalysis, which involves specific regulatory and inhibitory sites on the enzyme, and offer additional support for this model. Perturbation of the enzyme via such regulatory sites may provide new approaches to prophylaxis and therapy for poisoning by anticholinesterase compounds.