Study of Allergenic Properties of the Intermediate Antigens of Cerebral Vaccine against Tick-Borne Encephalitis,
FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO
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Intermediate antigens forming at different stages of tick-borne encephalitis virus growth in brain tissue were studied for their allergenic properties. The method of anaphylaxis and desensitization in guinea pigs was employed using tick-borne encephalitis vaccines prepared from the brain of infected mice having no clinical manifestations a two-day vaccine and from the brain of mice with clinical signs of illness a four-day vaccine. A normal brain suspension of mice was also used. The later showed only weak allergenic activity under given experimental conditions. Sensitization of guinea pigs with the two-day and four-day vaccines resulted in a strong anaphylactic reaction to their repeated introduction. The experiments have shown that intermediate antigens appear on the second day and increase in amount with the growth of the virus in cells and appearance of clinical manifestations in infected animals.