Accession Number:

ADA000961

Title:

Sequential Changes of Vascular Ultrastructure in Cerebral Vasospasm: Myonecrosis of Subarachnoid Arteries

Descriptive Note:

Scientific rept.

Corporate Author:

ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD

Personal Author(s):

• Fein, J. M.
• Flor, W. J.
• Parkhurst, L. J.
• Parker, J. L.

Report Date:

1974-06-01

Pagination or Media Count:

24.0

Abstract:

Cerebral vasospasm following subarachnoid hemorrhage may contribute to morbidity and mortality. The inconsistent therapeutic responses to sympatholytic agents described in the literature raise doubts as to the purely functional nature of the vasoconstriction. This study examines the ultrastructural evolution of vascuolar degeneration of the media in subarachnoid arteries which have been in spasm. The striking changes of myoarchitecture are described however, the relationship of these findings to aberrations in cerebral blood flow remains to be clarified.

Descriptors:

• *CEREBROVASCULAR SYSTEM
• *CONVULSIVE DISORDERS
• *HEMORRHAGE
• ARTERIES
• BLOOD CIRCULATION
• BRAIN
• CEREBRUM
• HISTOLOGY
• NEUROLOGY
• PATHOLOGY
• SYMPATHOLYTIC AGENTS
• VASOCONSTRICTING

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE