The Effects of Local Supralethal Irradiation on Renal Function
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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Clearance studies were performed in 16 dogs with surgically formed hemibladders to evaluate the intrinsic renal effects of 2000 rads of x rays administered as a single dose to the left kidney. These studies were conducted under conditions of water diuresis in 10 dogs on days 1, 7 and 14 postexposure. Results of the studies indicate that the earliest effects of radiation are related to the ability of the proximal tubule to reabsorb sodium and are manifested by both an increase in the fractional and absolute excretion of sodium within 24 hours of exposure, which continues throughout the interval of the study, and by a marked increase in the excretion of CH2O within a day of exposure, which becomes greater with time. Approximately three weeks postexposure, but before glomerular filtration rate declines, the concentrating segment of the nephron is impaired. These studies suggest that renal tubular injury is the major early effect of radiation.