Accession Number:

ADA000679

Title:

The Conversion of Cortisone into Cortisol in the Liver of Guinea Pigs during Allergic Processes of Immediate and Delayed Types,

Descriptive Note:

Corporate Author:

FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s):

Report Date:

1974-10-30

Pagination or Media Count:

14.0

Abstract:

A study was made of the intensity of transformaton of cortisone in to cortisol in anaphylactic alteration of the liver and against the background of experimentally-induced allergic encephalomyelitis EAE in guinea pigs under conditions of perfusion of the liver in situ. Introduction of normal horse serum from 0.02 to 0.2 mlml of the perfusate and egg crystalline albumin from 10 to 500 gammaml into the perfusate increase the intensity of cortisone transformation into cortisol in the liver of intact guinea pigs this increase was the greater -- the higher the dose of the antigen. In sensitized guinea pigs administration of the same antigens gave an opposite effect, i.e. a fall of the intensity of cortisol formation from cortisone. Against the background of EAE in animals suffering from marked pareses, the intensity of cortisol formation was greater than in intact animals with any concentration of cortisone in the inflowing perfusate. this evidently serves as one of the causes of an increase of cortisol in guinea pigs with EAE.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE