Accession Number:

ADA000656

Title:

Preliminary Assessment of Relative Toxicity of Candidate Louse Toxicant OMS-869 O,O-Dimethyl-O-(4-Cyanophenyl)-Phosphorothioate Evaluation of Animal Exposure Data and Recommendation Concerning a Sleeve Test Program.

Descriptive Note:

Rept. for Aug 67-Mar 74,

Corporate Author:

ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD

Personal Author(s):

• Weeks,Maurice H.

Report Date:

1974-01-01

Pagination or Media Count:

29.0

Abstract:

Preliminary assessment of the relative toxicity of a proposed louse toxicant O,O-dimethyl-O-4-cyanophenyl-phosphorothioate, OMS-869, was conducted using laboratory animals. The technical grade compound did not produce primary irritation when applied to the intact or abraded skin of rabbits. Data obtained from 21 days of continuous application of either technical grade chemical or a one percent formulation in pyrax powder to intact and abraded rabbit skin, and skin sensitization studies in guinea pigs did not indicate a potential hazard under the proposed conditions of use. Modified author abatract

Descriptors:

• *Insect repellents
• *Lice
• *Irritant compounds
• Toxicology
• Bioassay
• Laboratory animals
• Skin(Anatomy)
• Sensitivity
• Humans
• Eye

Subject Categories:

• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE