Biochemical Mechanisms and Physiological Effects of Work-induced Growth of Skeletal Muscle.
HARVARD MEDICAL SCHOOL BOSTON MASS DEPT OF PHYSIOLOGY
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The effects of nutrients, hormones and muscular contraction on protein turnover in skeletal muscle were investigated. One interesting finding has been that the supply of branched chain amino acids promotes protein synthesis and retards protein catabolism in muscle. By contrast other plasma amino acids do not affect protein balance in the tissue. The findings may be related to the fact that skeletal muscle selectively degrades these amino acids suggesting an interrelationship between the control of amino acids and muscle protein degradation. In addition to amino acids, supply of glucose and insulin were found to directly inhibit protein degradation as well as promote protein synthesis in muscles and there appears to be a large increase in protein degradation in inactive muscle. Modified author abstract