Accession Number:

ADA000364

Title:

Experimental Study of the Allergenic Properties of Dinitrochlorobenzene and araphenylenediamine with Different Means of Their Administration,

Descriptive Note:

Corporate Author:

FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Report Date:

1974-10-31

Pagination or Media Count:

14.0

Abstract:

Dinitrochlorobenzene DNKhB and paraphenylenediamine PFDA can be considered as potentially possible air allergens, which enter the atmosphere with the exhausts of industrial shops. The maximum permissible content of these two substances in the atmosphere has not been established. Only the maximum permissible concetration of DNKhB for industrial premises 0.001 mgz has been developed. Regarding the toxic concentrations of PFDA, 0.0024-0.000004 mgz are considered applicable to production conditions. Experimental research produced the following conclusions on allergenic properties of the compounds. Dinitrochlorobenzene and paraphenylenediamine in low concentrations 0.001 mzz possess a strong anaphylactogenic action which can be observed experimentally by reproducing the model of anaphylactic shock. The speed and acuteness of the development of the phenomena of anaphylactic shock in animals, depends not only on the state of their sensitization, but also on the dose of the allergen. In experimental reproduction of anaphylactic shock, the most effective method is the intraperitoneal adminstration of the chemical allergens. One should remember in experimental work with chemical allergens their parallel toxic action, which sometimes facilitates the simultaneous onset of a pattern of painful shock.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE