In Vitro Stimulation of Lymphocytes from Guinea Pigs Immunized with the Agent of Meningopneumonitis.
Medical research interim rept. no. 5,
NAVAL MEDICAL RESEARCH INST BETHESDA MD
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These studies were undertaken in preparation for an extensive investigation of the association of cell-mediated immunity to chlamydial agents to clinical nongonococcal urethritis. Spleen cells from guinea pigs immunized with the meningopneumonitis strain of Chlamydia psittaci MN derived from infected chicken embryos were made to react with MN antigen derived from cell cultures. Lymphocytic blastogenic transformation, production of lymphotoxin, and of migration inhibition factor were demonstrated. The results indicate that these tests can be performed with considerable simplicity with chlamydial antigens. These studies were not applied to nongonococcal urethritis because of the untimely death of Dr. Gordon. Author
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