Accession Number:

AD1190480

Title:

Mutational Landscape of the Y Chromosome and Prostate Cancer

Descriptive Note:

[Technical Report, Final Report]

Corporate Author:

SLOAN-KETTERING INST FOR CANCER RESEARCH NEW YORK

Personal Author(s):

• Schultz, Nikolaus

Report Date:

2022-10-01

Pagination or Media Count:

33

Abstract:

Mortality from prostate cancer PC, an estimated 33,330 deaths in 2020, is associated with developmentof aggressive and treatment-insensitive metastatic castration-resistant prostate cancer mCRPC. We willinvestigate the status and role of Y chromosome ChrY genes in regulating drug sensitivity and mCRPCdevelopment and progression. Though ChrY loss in men is associated with increased risk of disease andmortality, the role of ChrY genes in regulating PC progression is poorly understood. To investigate theclinical impact of ChrY gene expression, we developed new methodology to analyze mutational variants ofChrY genes in PC patient cohorts, previously unsuccessful due to the high number of repetitive sequencesand paralog families. Using a custom reference for each paralog family, our method increased ChrY readdepth coverage to be on par with whole-exome sequencing allowing for normaltumor variant calling.

Descriptors:

• medical personnel
• chromosomes
• genetics
• sequence analysis
• biomedical research
• cancer
• united states
• androgen receptors
• cells
• department of defense
• dna sequence analysis
• genomic instability
• neoplasms
• oncology
• prostate cancer
• cell line
• gene expression

Subject Categories:

Distribution Statement:

[A, Approved For Public Release]