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Interrogation of Requisite Niche Factors for Leukemia Cell Survival at Single-Cell Resolution
[Technical Report, Annual Report]
MASSACHUSETTS INST OF TECH CAMBRIDGE
Pagination or Media Count:
The goal of this project is to identify the signals within the bone marrow microenvironmentthat allow acute myeloid leukemia AML cells to survive and proliferate. By identifyingthese signals, we can improve cell culture systems for maintaining AML cells outside of thebody to study their true biology. We can also identify specific signals that are uniquelyrequired by AML cells inside the bone marrow microenvironment, but are not needed by healthycells in the rest of the body, and target these signals for AML-specific treatment withpotentially minimal effect on normal, healthy cells. We study this question primarily in awell known mouse model of AML, with confirmation of our mouse model findings in human AMLbiopsy samples.
[A, Approved For Public Release]