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Novel Dynamic Proteomics Approaches to Investigate the Systems Level Pathology of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)

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[Technical Report, Annual Report]

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MECFS is a severely debilitating condition characterised by unexplained, persistent and relapsing chronic fatigue of unknownpathology, typically lasting in excess of 6 months, which is significantly exacerbated by bouts of exertionexercise. Despite itswidespread nature effecting 1-2 of the worlds population, little is still known regarding the underlying pathology drivingthese debilitating symptoms. The overall aim of this project is to use a novel dynamic proteomics approach to provide a real timemeasure of changes in metabolism across multiple tissues blood, skeletal muscle and CSF, of MECFS patients at rest andfollowing an acute exercise stressor designed to elicit symptoms. This will provide potential new therapeutic targets fortranslational to the clinical settting in the near future. This report provides an update of progress to date, highlighting the issueswith volunteering particularly. We are currently struggling to recruit to the healthy volunteer group, however have had moreinterest within the MECFS group, with 4-5 potential volunteers due to be screened in the next few months hopefully.

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[A, Approved For Public Release]