Accession Number:

AD1186122

Title:

Phase Separation of FUS: A Potential Therapeutic Target in Cancer and Neurodegeneration

Descriptive Note:

[Technical Report, Doctoral Thesis]

Corporate Author:

UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD

Personal Author(s):

• Owen, Izzy

Report Date:

2021-08-31

Pagination or Media Count:

158

Abstract:

Myxoid liposarcoma is caused by a chromosomal translocation resulting in a fusion protein comprised of the N-terminus of FUS fused in sarcoma and the full-length transcription factor CHOP CCAATEnhancer Binding Protein Homologous Protein.FUS functions in RNA metabolism and CHOP is a stress-induced transcription factor. The FUS-CHOP fusion protein causes unique gene expression and oncogenic transformation.

Descriptors:

Subject Categories:

Distribution Statement:

[A, Approved For Public Release]