Accession Number:

AD1182982

Title:

Comparison of Preoperative Methylprednisolone and Ibuprofen on Mandibular Anesthesia Efficacy

Descriptive Note:

[Technical Report, Master's Thesis]

Corporate Author:

UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD

Personal Author(s):

• Clark, Jeffrey M.

Report Date:

2021-06-01

Pagination or Media Count:

30

Abstract:

Effective pain control is vital to the practice of modern dentistry. Mandibular pulpal anesthesia is commonly achieved using an inferior alveolar nerve block IANB. Irreversible pulpitis however, can reduce IANB success to as low as 20. This high failure rate has been attributed to the inflammatory process. Both nonsteroidal anti-inflammatory medications NSAIDs, and corticosteroid medications have been reported to increase IANB success in inflamed tissues. One clinical trial demonstrated the superiority of a steroid medication over NSAIDs in non-inflamed tissues. To date, no study has compared these two medications in inflamed pulp tissue. This prospective, double-blind, randomized clinical trial will compare IANB success inpatients with symptomatic irreversible pulpitis when given ibuprofen or methylprednisolone prior to initiating endodontic treatment.

Descriptors:

• health services
• anesthesia
• teeth
• proteins
• cells
• drug therapy
• blood
• cellular structures
• anesthetics
• clinical trials
• epinephrine
• pharmacokinetics
• sequential analysis
• statistical analysis
• data science
• information science

Subject Categories:

• Medicine and Medical Research
• Pharmacology

Distribution Statement:

[A, Approved For Public Release]