Accession Number:

AD1182968

Title:

Sarm1 as a Therapeutic Target for Chronic White Matter Pathology Following Experimental Traumatic Brain Injury

Descriptive Note:

[Technical Report, Doctoral Thesis]

Corporate Author:

UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD

Personal Author(s):

• Bradshaw, Donald V Jr

Report Date:

2021-03-19

Pagination or Media Count:

114

Abstract:

Traumatic brain injury TBI can have long term consequences that include neurodegeneration and persistent symptoms. White matter tracts, such as the corpus callosum CC, are particularly vulnerable and are associated with functional outcomes and potential neurodegenerative processes. Treatments are needed to protect axons from early traumatic axonal injury TAI and mitigate secondary mechanisms that lead to latest age neurodegeneration and atrophy. The SARM1 sterile alpha and Tollinterleukin-1receptor motif containing 1 gene has been identified as a master executioner of the axon degeneration pathway and has become a significant target of interest in the development of therapeutic strategies to prevent axonal degradation. Our previous work demonstrated that mice with genetic deletion of Sarm1 exhibit significantly less acute axon damage and demyelination following a model of concussive TBI. This project aimed to determine if the constitutive absence of Sarm1 attenuates chronic white matter pathology and behavioral deficits following experimental TBI.

Descriptors:

• health services
• medical personnel
• brain injuries
• brain
• neurodegeneration
• stem cells
• cells
• genetics
• neuroglia
• confocal microscopy
• neuroimaging
• peripheral nervous system
• chemistry
• neurosciences
• three dimensional
• blood

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]