Accession Number:

AD1182844

Title:

Identifying Molecular Driver Events in Salivary Acinic Cell Carcinomas

Descriptive Note:

[Technical Report, Master's Thesis]

Corporate Author:

UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD

Personal Author(s):

• Seedall, Matthew E

Report Date:

2020-06-24

Pagination or Media Count:

24

Abstract:

Salivary acinic cell carcinoma AcCC is typically a low-grade adenocarcinoma found most commonly in the parotid gland. These tumors can undergo high grade transformationHGT and loco-regional recurrence and metastases. Histopathology of this tumor is characterized by acinar differentiation. This histopathology suggests conserved genetic driver events which immortalize cells. Recently NR4A3 has been reported as an oncogenic transcription factor in AcCC.

Descriptors:

• medical personnel
• carcinoma
• salivary glands
• neoplasms
• materials
• oncology
• parotid glands
• tissues
• cancer
• lymphatic system
• acinar cells
• cell physiological processes
• cells
• chemical reactions
• demographic cohorts
• immunohistochemistry
• immunostaining

Subject Categories:

• Medicine and Medical Research
• Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]