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Prothrombin Complex Concentrate for Prolonged Field Care of War Casualties
[Technical Report, Annual Report]
OREGON HEALTH AND SCIENCE UNIV PORTLAND
Pagination or Media Count:
Patients who initially survive from traumatic thoracic injury are at risk for Acute Respiratory Distress Syndrome ARDS. The only proven treatments available once ARDS has developed are low tidal volume ventilation ARDSnet and proning, but there is no existing treatment strategy to prevent the onset of ARDS following traumatic injury. As a potential solution, recent evidence suggest that prothrombin complex concentrate Kcentra acts similarly to plasma to prevent vascular leak and edema, but this has not been investigated in the trauma setting. Therefore, the purpose of this project is to conduct a series of in vitro and in vivo studies to determine if the therapeutic administration of Kcentra prevents the development of ARDS following pulmonary contusion and hemorrhagic shock.
[A, Approved For Public Release]