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The Survival Factor Renalase and Pancreatic Cancer
[Technical Report, Final Report]
YALE UNIV NEW HAVEN CT
Pagination or Media Count:
This proposal relates to the FY18 CDMRP topic area of Pancreatic Cancer. The project explores the role of a novel survival factor, the secretory protein renalase. We examine its potential value as a disease biomarker as well as its function to promote pancreatic cancer growth. We reported that renalase levels are increased in some pancreatic cancer tissue and that the levels correspond inversely with survival. Clinically, we propose to use human samples to examine whether plasma levels of renalase will also correspond to survival and whether tissue renalase levels are increased in pre-malignant conditions of the pancreas such as chronic pancreatitis and intrapancreatic mucinous neoplasms. Mechanistically, we will study whether renalase directly affects human pancreatic cancer cell growth by examining human cancer organoids. Using this new cancer model, we will examine the effects of added renalase or an inhibitory antibody we developed. If our predictions are correct, these studies could lead to a new biomarker that could guide pancreatic cancer therapy, including surgery, and could lead to a new form of therapy that uses the inhibition of renalase to reduce pancreatic cancer growth.
[A, Approved For Public Release]