Accession Number:

AD1168870

Title:

Reinnervation of Paralyzed Limb Muscle by Nerve-Muscle-Endplate Grafting Technique

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

Hackensack Meridian Health

Personal Author(s):

• Mu, Liancai
• Chen, Jingming
• Li, Jing
• Sobotka, Stanislaw
• Nyirenda, Themba

Report Date:

2022-05-01

Pagination or Media Count:

99

Abstract:

In our previous annual report, we presented outcomes of the NMEG-NMZ technique and standard nerve-end-to-end anastomosis EEA technique control for limb reinnervation. Overall, the NMEG-NMZ NN resulted in better functional recovery 79 of the control compared to the EEA 51. Here, we summarize the data obtained from animals in the Imm-NNENF, Imm-NNES, and Imm-ANG technique control groups. Three months after treatment, outcomes were evaluated by measuring toe spread distances and muscle force, quantifying the extent of axonal regeneration in the target muscle, determining the percentage of reinnervated motor endplates MEPs,measuring muscle weight and examining fiber-type distribution. Our results showed that Imm-NNENF and ImmNNES resulted in more optimal functional recovery 90 and 85, respectively as compared with NMEG-NMZ alone 79 and Imm-ANG 46. The results confirm that the adjunctive therapies ENF and ES have the potential for improving the outcomes of the NMEG-NMZ surgery in the rat immediate limb reinnervation model.

Descriptors:

• health services
• medical personnel
• peripheral nervous system
• skeletal muscle
• laboratory animals
• electronic mail
• surgery
• united states
• body regions
• sciatic nerve
• standards
• anesthesia
• cameras
• dermatologic agents
• measurement
• muscles

Subject Categories:

• Medicine and Medical Research
• Anatomy and Physiology

Distribution Statement:

[A, Approved For Public Release]