Accession Number:

AD1166810

Title:

Using Multimodal Imaging to Examine the Neural Mechanisms of an Integrative Exercise Program for Individuals with Dementia

Descriptive Note:

[Technical Report, Final Report]

Corporate Author:

NORTHERN CALIFORNIA INST FOR RESEARCH AND EDUCATION SAN FRANCISCO

Personal Author(s):

• Chao , Linda

Report Date:

2021-11-01

Pagination or Media Count:

29

Abstract:

The goal of this project is to investigate whether participation in the Preventing Loss of Independence through Exercise PLIE program for 4 months will result in neurobiological changes that improve cognitive function, leading to improvements in physical function and quality of life QOL. We will estimate the impact of PLIE on brain atrophy rates, Default Mode Network DMN functional connectivity, and cerebral perfusion and determine if improvements in cognition, function, and QOL are associated with changes in brain volume, DMN functional connectivity, and cerebral perfusion in individuals who participated in PLIE.

Descriptors:

Subject Categories:

• Medicine and Medical Research
• Psychology
• Stress Physiology

Distribution Statement:

[A, Approved For Public Release]