Using Multimodal Imaging to Examine the Neural Mechanisms of an Integrative Exercise Program for Individuals with Dementia
[Technical Report, Final Report]
NORTHERN CALIFORNIA INST FOR RESEARCH AND EDUCATION SAN FRANCISCO
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The goal of this project is to investigate whether participation in the Preventing Loss of Independence through Exercise PLIE program for 4 months will result in neurobiological changes that improve cognitive function, leading to improvements in physical function and quality of life QOL. We will estimate the impact of PLIE on brain atrophy rates, Default Mode Network DMN functional connectivity, and cerebral perfusion and determine if improvements in cognition, function, and QOL are associated with changes in brain volume, DMN functional connectivity, and cerebral perfusion in individuals who participated in PLIE.
- Medicine and Medical Research
- Stress Physiology