Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury (The CONNECT-TBI Trial)
[Technical Report, Annual Report]
NEW MEXICO UNIV HEALTH SCIENCES CENTER ALBUQUERQUE
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The objective of this application is to conduct a clinical trial of APT-3 combined with targeted neuromodulation to treat cognitive control deficits in complex mTBI. Veterans and Servicemembers with mTBI and cognitive symptoms will be recruited from the New Mexico and Minneapolis VA Polytrauma clinics. Participants will undergo baseline demographic, neuropsychological, and quality of life testing, as well as restingtask-related fMRI. They will be randomized to 4 weeks of computer-based APT with concurrent rTMS, HD-tDCS, or sham stimulation delivered to the dorsolateral prefrontal cortex DLPFC. Lastly, they will repeat all baseline tests, and report on 3- and 6-month recovery levels. Our central hypotheses are Aim 1 targeted neuromodulation applied to the DLPFC, when paired with APT-3, will facilitate the greatest improvement in cognitive control for the rTMS group rTMSHD-tDCSsham Aim 2 these interventions will result in improvements in functional measures andquality of life Aim 3 fMRI will identify changes in CCN activation associated with cognitive control deficits and recovery.
- Medicine and Medical Research