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Developing New Therapeutic Strategies for Malignant Peripheral Nerve Sheath Tumor by Interrupting Immunologic Tolerance
[Technical Report, Final Report]
NATIONWIDE CHILDREN'S HOSPITAL COLUMBUS OH
Pagination or Media Count:
Based on recent data from us and others using human clinical MPNST specimens, we seek validation inmouse models of a novel treatment paradigm that could lead to new clinical trials. Our approach is based onstimulating antitumor immunity using oncolytic virus infections combined with inhibitors ofimmunosuppression, including those targeting TGF both directly and indirectly, through the Janus kinaseinhibitor Ruxolitinb and T cell checkpoints.
[A, Approved For Public Release]