Accession Number:

AD1166360

Title:

Developing New Therapeutic Strategies for Malignant Peripheral Nerve Sheath Tumor by Interrupting Immunologic Tolerance

Descriptive Note:

[Technical Report, Final Report]

Corporate Author:

NATIONWIDE CHILDREN'S HOSPITAL COLUMBUS OH

Personal Author(s):

• Cripe, Timothy

Report Date:

2021-12-01

Pagination or Media Count:

30

Abstract:

Based on recent data from us and others using human clinical MPNST specimens, we seek validation inmouse models of a novel treatment paradigm that could lead to new clinical trials. Our approach is based onstimulating antitumor immunity using oncolytic virus infections combined with inhibitors ofimmunosuppression, including those targeting TGF both directly and indirectly, through the Janus kinaseinhibitor Ruxolitinb and T cell checkpoints.

Descriptors:

• health services
• medical personnel
• lymphocytes
• proteins
• therapy
• cells
• biomedical research
• combination therapy
• department of defense
• peptides
• peripheral nervous system
• immunity
• immunotherapy
• chemistry
• cytokines
• oncolytic viruses

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]