Accession Number:

AD1166359

Title:

Airborne Pollutants as Triggers of Parkinson's Disease via the Olfactory System

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES

Personal Author(s):

• Finch, Caleb E

Report Date:

2021-10-01

Pagination or Media Count:

30

Abstract:

We are interested in determining whether ambient air pollutants impact the development of Parkinsons disease PD by increasing alpha-synuclein pathology via inflammation. After completing Specific Aim 2, wherein we found no differences between experimental groups in spread of alpha-syn, nor the expected nPM-induced neuroinflammatory changes. We repeated Specific Aim 2 mouse experiments with a new batch of nPM that showed in vitro activity. We collected tissues during the first week of SARS-CoV-2 quarantine. After restrictions were relaxed, we began analyzing tissues for neuroinflammation. This on-going analysis has yet to show strong inflammatory effects of the in vivo nPM exposure. Due to continued pandemic quarantine and travel restrictions we are discussing option with our collaborators. We will plan and execute novel experiments to explore the effects of LPS-induced olfactory inflammation on spread of alpha-syn by histological VAI and biochemical USC analyses.

Descriptors:

• health services
• medical personnel
• brain
• parkinson's disease
• chemistry
• dementia
• chemical synthesis
• covid-19
• nanoparticles
• alzheimer disease
• neurodegeneration
• air pollutants
• diseases and disorders
• quarantine
• air pollution
• cerebral cortex
• health

Subject Categories:

• Medicine and Medical Research
• Biochemistry
• Medicine and Medical Research
• Biochemistry

Distribution Statement:

[A, Approved For Public Release]