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HER2 Expression in African American Men with Prostate Cancer
[Technical Report, Annual Report]
CITY OF HOPE BECKMAN RESEARCH INST DUARTE CA
Pagination or Media Count:
African American AA men suffer from increased prostate cancer PCaincidence and mortality.1 Gene expression profiles confirm prominent racial differences in tumor biology, and a variety of pro-tumorigenic genes are differentially expressed in AA men.2-5Human epidermal growth factor receptor-2 HER2 is a tyrosine kinase involved in the promotion of cellular division and suppression of apoptosis and is correlated with worse prognosis and treatment resistance in PCa patients, but this gene has not been evaluated in AAmen.6,7 Clinical trials targeting HER2 were previously initiated in PCa patients. There is no indication that racial differences in HER2 expression were evaluated.8-11 There is an urgent need to better understand the biology contributing to the worse prognosis observed in AA PCa patients in order to 1 predict which men are more likely to suffer from lethal disease and 2develop more patient-specific treatments. In this study, we seek to establish that HER2expression promotes cellular growth, clonogenicity, and migration in a racially diverse panel of PCa cell lines confirm whether HER2 overexpression is positively correlated with West African ancestry WAA in tumor tissue specimens and determine if HER2 overexpression correlates with disease stage, clinical features, treatments, and outcomes in PCa patients.
[A, Approved For Public Release]