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Mechanisms and Treatment of Deployment-Related Lung Injury: Repair of the Injured Epithelium

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[Technical Report, Annual Report]

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This research uses an infrastructure and cohort of over 100 previously deployed military personnel with symptoms of lung disease who are currently treated in the Center for Deployment Lung Disease, led by Dr. Cecile Rose at National Jewish Health. Our focus is on how exposure to airborne particles acting in concert with physical forces e.g. blast injury chemical toxicants, and allergens may damage the lung epithelial cells and may lead to lung disease. Divided into four projects, we use existing clinical data and biological samples from previously deployed military personnel with symptoms of lung disease. These samples are used to determine what kind and how much lung injury results from deployment-related exposures. In parallel, using a combination of cell culture and animal models of lung injury, we characterize using cellular and molecular techniques, how these exposures contribute to lung damage. We are investigating an innovative approach to the treatment of this lung damage using experimental drugs that promote healing of injured lungs. Our goal is to be able to predict which military personnel are susceptible to the toxic effects of airborne particulate matter, use preventative measures to minimize any damage to the lung, and initiate treatment at the earliest signs of disease.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology

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[A, Approved For Public Release]