Accession Number:

AD1161255

Title:

Regulatory Immune Mechanisms and Gastrointestinal Comorbidity in ASD

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

CALIFORNIA UNIV DAVIS

Personal Author(s):

Report Date:

2021-10-01

Pagination or Media Count:

7

Abstract:

Nearly half of all children with autism spectrum disorders ASD also have co morbid gastrointestinal GI symptoms that can affect behavior through a brain-immune gut feedback loop. The primary GI condition is due to uncontrolled inflammation. The main objectives of this project are 1 to characterize defects in Tregs function and ability to suppress responses 2 to identify epigenetic mechanisms that control Tregs lineage commitment and 3 to determine the stability of Tregs under inflammatory conditions and the Tregs- T helper TH17 balance, in children with ASD and GI symptoms. Our main hypothesis is that Tregs dysfunction causes a lack of immune control in children with ASD who experience GI co-morbidities.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]