Regulatory Immune Mechanisms and Gastrointestinal Comorbidity in ASD
[Technical Report, Annual Report]
CALIFORNIA UNIV DAVIS
Pagination or Media Count:
Nearly half of all children with autism spectrum disorders ASD also have co morbid gastrointestinal GI symptoms that can affect behavior through a brain-immune gut feedback loop. The primary GI condition is due to uncontrolled inflammation. The main objectives of this project are 1 to characterize defects in Tregs function and ability to suppress responses 2 to identify epigenetic mechanisms that control Tregs lineage commitment and 3 to determine the stability of Tregs under inflammatory conditions and the Tregs- T helper TH17 balance, in children with ASD and GI symptoms. Our main hypothesis is that Tregs dysfunction causes a lack of immune control in children with ASD who experience GI co-morbidities.
- Medicine and Medical Research