Accession Number:

AD1161242

Title:

Environmental Fate of Dexmedetomidine in Soil and Relevant Waters

Descriptive Note:

[Technical Report, Final Report]

Corporate Author:

U.S. Army Combat Capabilities Development Command Chemical Biological Center

Report Date:

2022-02-01

Pagination or Media Count:

30

Abstract:

The objectives of this work were to assess the stability and persistence of dexmedetomidine in four soil types and water collected from eight different sources and to determine the distribution of dexmedetomidine when it is in contact with soil and water for as long as 12 weeks. Soil samples in contact with 0.01 M calcium chloride solution were spiked with a known amount of dexmedetomidine in solution and then were extracted after several contact time periods to track compound recovery and distribution. The water samples were spiked with a known amount of dexmedetomidine, and aliquots were taken for analysis after multiple time periods. The results showed that the amount of dexmedetomidine recovered from soil extracts accounted for 2898 of the spike, and smaller amounts were recovered from the supernatant. More than 80 of dexmedetomidine was recovered from each of the water samples during this 12 week trial. These results indicate that dexmedetomidine is relatively stable in water and moist soils. The current data also suggest that dexmedetomidine is persistent with some mobility into groundwater, depending on soil type.

Subject Categories:

  • Soil Mechanics
  • Hydrology, Limnology and Potamology

Distribution Statement:

[A, Approved For Public Release]