The Role of Mitochondria in ADT-Induced Sarcopenia in Prostate Cancer Patients
[Technical Report, Annual Report]
SEATTLE INST FOR BIOMEDICAL AND CLINICAL RESEARCH SEATTLE WA
Pagination or Media Count:
Prostate cancer PCa is the most common cancer among men. Androgen deprivation therapy ADTis the standard treatment for advanced and metastatic PCa and nearly 400,000 men remain onandrogen deprivation therapy ADT for advanced PCa in the U.S. Unfortunately, ADT alsoinduces a decrease in muscle mass and function, known as sarcopenia, a condition that leadsto decreased endurance, increased fatigue, falls, poor health-related quality of life HRQOL and increased mortality. The mechanisms underlying the development of ADT-inducedsarcopenia are incompletely understood and remain a significant barrier to the development oftherapies for this condition. Mitochondria play an essential role in generating the adenosinetriphosphate ATP needed for muscle contraction and abnormalities in mitochondria functionhave been reported in animal models of sarcopenia. The extent to which mitochondrialdysfunction mediates ADT-induced sarcopenia and muscle dysfunction is not known.
- Medicine and Medical Research