Accession Number:

AD1160971

Title:

The Role of Mitochondria in ADT-Induced Sarcopenia in Prostate Cancer Patients

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

SEATTLE INST FOR BIOMEDICAL AND CLINICAL RESEARCH SEATTLE WA

Personal Author(s):

• Garcia, Jose M

Report Date:

2021-09-01

Pagination or Media Count:

23

Abstract:

Prostate cancer PCa is the most common cancer among men. Androgen deprivation therapy ADTis the standard treatment for advanced and metastatic PCa and nearly 400,000 men remain onandrogen deprivation therapy ADT for advanced PCa in the U.S. Unfortunately, ADT alsoinduces a decrease in muscle mass and function, known as sarcopenia, a condition that leadsto decreased endurance, increased fatigue, falls, poor health-related quality of life HRQOL and increased mortality. The mechanisms underlying the development of ADT-inducedsarcopenia are incompletely understood and remain a significant barrier to the development oftherapies for this condition. Mitochondria play an essential role in generating the adenosinetriphosphate ATP needed for muscle contraction and abnormalities in mitochondria functionhave been reported in animal models of sarcopenia. The extent to which mitochondrialdysfunction mediates ADT-induced sarcopenia and muscle dysfunction is not known.

Descriptors:

• health services
• medical personnel
• body composition
• department of veterans affairs
• lung diseases
• neoplasms
• quality of life
• diseases and disorders
• prostate cancer
• biomedical research
• clinical trials
• department of defense
• training
• united states
• cancer
• health care

Subject Categories:

• Biochemistry
• Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]