Accession Number:

AD1160543

Title:

Precision Combinatorial Immunotherapeutic Targeting of Cytokine Receptor Kinase Signaling in CRLF2-Rearranged ALL

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

COLORADO UNIV AURORA CO

Personal Author(s):

• Fry, Terry
• Tasian, Sarah

Report Date:

2021-10-01

Pagination or Media Count:

21

Abstract:

Ph-like ALL is a high-risk subset of B-ALL defined by an activated kinase gene expression profile similar to that of BCR-ABL1-rearranged Ph ALL and driven by a diverse range of genetic alterations that activate cytokine receptor signaling pathways. Children, AYAs, and older adults with Ph-like ALL have 60 relapse risk and experience significant leukemia-associated mortality. Approximately 50 of Ph-like ALL cases harbor rearrangements in CRLF2 CRLF2-R and frequent concomitant JAK2 point mutations. In addition to patients with Ph-like ALL, CRLF2 rearrangements usually P2RY8-CRLF2 fusions with JAK2 point mutations occur in approximately 60 of children and AYAs with trisomy 21Down Syndrome-associated ALL DS-ALL and also induce hyperactive JAKSTAT signaling. Children with DS-ALL have substantial toxicity with chemotherapy and inferior clinical outcomes.

Descriptors:

• health services
• department of defense
• medical personnel
• antigens
• biomedical research
• culture techniques
• cell line
• clinical trials
• lymphocytes
• neoplasms
• precision
• cells
• cytokines
• engineering
• covid-19
• data analysis
• genetics

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]