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The Role of Mesothelial Omentin in Ovarian Cancer Progression
[Technical Report, Final Report]
UNIVERSITY OF SOUTH FLORIDA TAMPA
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We hypothesize that omentin ITLN1 suppresses ovarian cancer progression by sequestering lactotransferrin LTF from its receptor LRP1 on the ovarian cancer cells and adipocytes, and that lactotransferrin promotes ovarian cancer cells motility and growth. The most significant finding in this research period are 1 exogenous omentin suppresses ovarian cancer cells motility and invasive potential, 2 matrix etalloproteinase-1 MMP1 mediated the effects of omentin on suppressing ovarian cancer cells motility and invasive potential, 3 ITLN1 abrogates LTFs effects on ovarian cancer cells motility and invasive potential 4 omentin suppressed ovarian cancer growth by enhancing insulin-dependent glucose inadipocytes via facilitative glucose transporter GLUT4SLC2A4, and 5 exogenous omentin suppressed ovarian cancer progression in vivo.
[A, Approved For Public Release]