Accession Number:

AD1160541

Title:

The Role of Mesothelial Omentin in Ovarian Cancer Progression

Descriptive Note:

[Technical Report, Final Report]

Corporate Author:

UNIVERSITY OF SOUTH FLORIDA TAMPA

Personal Author(s):

• Yip, Kay-Pong

Report Date:

2021-08-01

Pagination or Media Count:

60

Abstract:

We hypothesize that omentin ITLN1 suppresses ovarian cancer progression by sequestering lactotransferrin LTF from its receptor LRP1 on the ovarian cancer cells and adipocytes, and that lactotransferrin promotes ovarian cancer cells motility and growth. The most significant finding in this research period are 1 exogenous omentin suppresses ovarian cancer cells motility and invasive potential, 2 matrix etalloproteinase-1 MMP1 mediated the effects of omentin on suppressing ovarian cancer cells motility and invasive potential, 3 ITLN1 abrogates LTFs effects on ovarian cancer cells motility and invasive potential 4 omentin suppressed ovarian cancer growth by enhancing insulin-dependent glucose inadipocytes via facilitative glucose transporter GLUT4SLC2A4, and 5 exogenous omentin suppressed ovarian cancer progression in vivo.

Descriptors:

Subject Categories:

• Biochemistry
• Genetic Engineering and Molecular Biology
• Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]