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Prostate Specific Membrane Antigen-Dependent Health Disparities in Prostate Cancer

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[Technical Report, Annual Report]

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According to published data, African American AA men AA men are 1.6 times more susceptible to develop prostate cancer, and about 2 times more likely to die from this disease than men of European EUR decent. In fact, even when environmental factors are corrected for, the disparity in mortality rate between AA and EUR men is higher for prostate cancer than that for any other malignancy thus suggesting a molecular component. The Caromile lab is investigating if germ line single nucleotide polymorphisms, or SNPS, within certain components of the PSMA signaling pathway might contribute to the increased risk of prostate cancer in AA men vs that of EUR men. Investigation into these molecular mechanisms not only has the potential to improve the outcomes of all men with lethal prostate cancer but also has the capability to reduce prostate cancer disparities by improving detection, morbidity and mortality of lethal prostate cancer in AA and other at-risk populations through the identification of unique, tailored treatment and prevention strategies for each patient.


Subject Categories:

  • Medicine and Medical Research
  • Genetic Engineering and Molecular Biology

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[A, Approved For Public Release]