Accession Number:

AD1160532

Title:

Endogenous Retrovirus Expression, Chromatin Abnormalities, and Response to Immune Checkpoint Blockade in Clear Cell Renal Cell Cancer

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

RUTGERS - THE STATE UNIV NEW BRUNSWICK NJ

Personal Author(s):

• Ganesan, Shridar

Report Date:

2021-10-01

Pagination or Media Count:

11

Abstract:

In this study, we investigate the role of re-expression of endogenous retroviruses ERV as an alternative mechanism of immune activation that may be relevant in ccRCC. Our preliminary data demonstrate that ERVs, including ERV3.2 are highly expressed in a subset of ccRCC and this expression is associated with evidence of CD8 T-cell infiltration and with response to single agent immune checkpoint blockade. We have found that a subset of ccRCC have increased expression of specific immune checkpoints including LAG3, suggesting that novel LAG3 antibodies may be active in ccRCC. Treatment of ccRCC cell lines and models with epigenetic modifying agents can increase ERV expression. Analyses is ongoing in both cell models and tissue specimens to further investigate how ERV expression is associated with both chromatin changes and immune activation in renal cancer. Our overall aim is to investigate the mechanisms of dysregulated ERV expression in a subset of ccRCC and could function and its potential role as a biomarker of response to ICB.

Descriptors:

• lymphocytes
• rna sequence analysis
• medical personnel
• cells
• department of defense
• procurement
• acquisition
• cell line
• neoplasms
• data analysis
• standards
• therapy
• abnormalities
• biomedical research
• cancer
• chromosome structures
• clinical trials

Subject Categories:

• Medicine and Medical Research
• Anatomy and Physiology
• Biochemistry

Distribution Statement:

[A, Approved For Public Release]