Targeting Piezo Ion Channels for Mitigation of Osteoarthritis Pain and Disease Progression
[Technical Report, Annual Report]
MASSACHUSETTS GENERAL HOSPITAL BOSTON
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The purpose of this project is to determine the roles of Piezo mechano-sensing channels in osteoarthritis OA and pain associated with OA using mouse genetic models. Two major aims are proposed.1 assessment of the effect of cartilage-specific loss of Piezo1 and Piezo2 in OA progression in surgically created OA in mice, and 2 assessment of OA-associated pain in Piezo2 haplo-insufficient mice.
- Medicine and Medical Research