Accession Number:

AD1159625

Title:

Targeting Piezo Ion Channels for Mitigation of Osteoarthritis Pain and Disease Progression

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

MASSACHUSETTS GENERAL HOSPITAL BOSTON

Personal Author(s):

• Kobayashi, Tatsuya

Report Date:

2021-10-01

Pagination or Media Count:

9

Abstract:

The purpose of this project is to determine the roles of Piezo mechano-sensing channels in osteoarthritis OA and pain associated with OA using mouse genetic models. Two major aims are proposed.1 assessment of the effect of cartilage-specific loss of Piezo1 and Piezo2 in OA progression in surgically created OA in mice, and 2 assessment of OA-associated pain in Piezo2 haplo-insufficient mice.

Descriptors:

• cartilage
• health services
• medical personnel
• disease attributes
• pain
• arthritis
• biomedical research
• diseases and disorders
• breeding
• connective tissue cells
• students
• targeting
• ablation
• animals
• bone and bones
• genetics
• hospitals

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]