Proteomic Discovery of Potential Biomarkers in Zika Virus Infected Monkeys
[Technical Report, Final Report]
Combat Capabilities Development Command Chemical Biological CenterU.S. Army 20th CBRNE CommandExcet, Inc.
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Zika virus ZIKV was first discovered in Macaca mulatta rhesus monkeys in 1947 and was found in humans in 1952. This virus can be transmitted via the bite of an infected mosquito, through sexual transmission, or from mother to child. Although most infected individuals are asymptomatic, some clinical symptoms of the virus include fever, joint pain, and rash, as well as microcephaly in infants of infected mothers. The World Health Organization Geneva, Switzerland announced a public health emergency in 2016 in response to outbreaks of ZIKV and its association with microcephaly however, there has been limited progress in discerning how this virus impacts the host. Here, we report on the use of a proteomic pipeline to analyze plasma samples of ZIKV-infected macaques to identify biomarkers for the virus. The discovery of ZIKV biomarkers will assist in defining virus behavior during infection and will illustrate how the host is affected.
- Medicine and Medical Research