Accession Number:

AD1158234

Title:

Neuroimaging Endophenotypes and Predictors of Post-Traumatic Brain Injury Dementia in a Nationwide Cohort of Veterans

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

NORTHERN CALIFORNIA INST FOR RESEARCH AND EDUCATION SAN FRANCISCO

Personal Author(s):

Report Date:

2021-10-01

Pagination or Media Count:

54

Abstract:

The overall goal is to cost-efficiently harness the newly available wealth of nationwide clinical neuroimaging data and merge with our existing cohort of 1.6 million TBI-exposed and unexposed veterans with up to 12 years of follow-up in order to 1 create a large, nationwide, high-quality cohort of tilde200,000 TBI-exposed and un-exposed veterans with MRI imaging data 2 predict which TBI-exposed veterans will go on to develop dementia and 3 identify prevalence of specific sub-types of dementia among TBI-exposed versus unexposed veterans. We expect that we will 1 produce the largest military-relevant MRI dataset with expertly curated TBI exposure and dementia outcome and up to 12 years of follow-up with option of continued follow-up via VHA EMR 2 develop a method for predicting 5-year risk of post-TBI dementia using routinely collected clinical MRI. This work may directly inform public health planning within the DoD and VHA and generate testable hypotheses regarding underlying etiology of post-TBI dementia.

Descriptors:

Subject Categories:

  • Medicine and Medical Research
  • Weapons Effects (Biological)
  • Psychology

Distribution Statement:

[A, Approved For Public Release]