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Targeting the Gut Microbiome to Treat Post-Traumatic Osteoarthritis

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[Technical Report, Annual Report]

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While osteoarthritis OA is a debilitating condition with no disease modifying treatments, the gut microbiome may play a role in itsdevelopment and progression. The establishment of a disease modifying treatment of OA has immense ramifications, including improvedquality of life, lowered economic burden of treatment, and increased productivity of patients with OA. The purpose of this project is to studythe disease enhancing role of the gut microbiome in the development of OA as well as to develop microbiome-targeting treatments of thedisease. Fecal microbiota transplants FMTs will be used to examine the causal relationship between microbiome dysbiosis that maydevelop in veterans diagnosed with post-traumatic osteoarthritis PTOA and belonging to the Military and Veteran Microbiome Consortiumfor Research and Education MVM-CoRE. Treatment of PTOA with microbiome pre and probiotics has been ongoing, and we find thedietary supplement hydrolyzed hylaline cartilage hHC to have protective effects on cartilage degeneration in a mouse model of PTOA.Some of this data was presented in our technical report last year, and it is now developed adequately to be in a manuscript to be submittedthis fall Fall 2021. Despite residual institutional shutdowns caused by the COVID-19 pandemic, significant progress has been made on thefirst two objectives of this project, with progress expected to continue apace on all objectives


Subject Categories:

  • Medicine and Medical Research
  • Microbiology

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[A, Approved For Public Release]