A Precision Medicine Study of How Inflammation May Underlie the Excessive Burden of Prostate Cancer in Men of African Ancestry
[Technical Report, Annual Report]
GENEVA FOUNDATION TACOMA WA
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Objective Systemic low-grade inflammation is a prostate cancer risk factor in men of African descent, and correlates with West Africanancestry, genetic susceptibility, a distinct tumor biology, and aggressive disease. Our overall objective is to understand these relationshipswith a view to informing prevention and therapeutic strategies. Impact Our study will be the first to explore the relationship between systemicchronic inflammation, ancestry, and tumor biology as a cause of disease progression in men of African descent. Creating an understanding of how the interaction between chronic inflammation and tumor biology affects prostate cancer progression in a high-risk population, like African-American men, offers the opportunity to the develop improved prevention and therapeutic strategies using anti-inflammatory drugs and immune modulators to decrease the disease burden among all men.
- Medicine and Medical Research