Accession Number:

AD1158225

Title:

A Precision Medicine Study of How Inflammation May Underlie the Excessive Burden of Prostate Cancer in Men of African Ancestry

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

GENEVA FOUNDATION TACOMA WA

Personal Author(s):

Report Date:

2021-10-01

Pagination or Media Count:

95

Abstract:

Objective Systemic low-grade inflammation is a prostate cancer risk factor in men of African descent, and correlates with West Africanancestry, genetic susceptibility, a distinct tumor biology, and aggressive disease. Our overall objective is to understand these relationshipswith a view to informing prevention and therapeutic strategies. Impact Our study will be the first to explore the relationship between systemicchronic inflammation, ancestry, and tumor biology as a cause of disease progression in men of African descent. Creating an understanding of how the interaction between chronic inflammation and tumor biology affects prostate cancer progression in a high-risk population, like African-American men, offers the opportunity to the develop improved prevention and therapeutic strategies using anti-inflammatory drugs and immune modulators to decrease the disease burden among all men.

Descriptors:

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]