Blood-Based Exosomal A-Synuclein Aggregates as a Quantifiable Biomarker of Parkinson's Disease
[Technical Report, Annual Report]
Iowa City VA Research Foundation
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This study W81XWH2010811PD190043P1 aims to fulfill Objective 3 of the overall project titled as Blood-Based Exosomal alpha-Synuclein Aggregates as a Quantifiable Parkinsons Disease Biomarker. Aims of this study are to 1 cross-validate the misfolded alpha-Synuclein in red blood cell RBC-derived extracellular vesicles EVs as a biomarker of PD in a cohort US veterans, and 2 investigate the misfolded alphaSyn in RBC-derived EVs as a potential biomarker of prodromal PD in a cohort of US Vietnam veterans exposed to Agent Orange but who have not been diagnosed with PD. Studies to fulfill Objectives 1 and 2 developing the blood test and testing in animal models and humans are conducted by our collaborators at Iowa State University and University of Washington. The study has been launched at the Iowa City VA Medical Center and is behind recruitment target due to the COVID-19 pandemic, but we plan to catch up by expediting enrollment in upcoming quartersyears.
- Medicine and Medical Research