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Targeting the Gut Microbiome to Treat Post-Traumatic Osteoarthritis

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[Technical Report, Annual Report]

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While osteoarthritis OA is a debilitating condition with no disease modifying treatments, the gut microbiome may play a role in its development and progression. The establishment of a disease modifying treatment of OA has immense ramifications, including improvedquality of life, lowered economic burden of treatment, and increased productivity of patients with OA. The purpose of this project is to studythe pathogenic role of the microbiome in the development of OA as well as to develop microbiome-targeting treatments of the disease. Fecalmicrobiota transplants FMTs will be used to examine the causal relationship between microbiome dysbiosis that may develop in veteransdiagnosed with post-traumatic osteoarthritis PTOA and belonging to the Military and Veteran Microbiome Consortium for Research andEducation MVM-CoRE. Treatment of PTOA with microbiome pre and probiotics has been ongoing, and we find the dietary supplementhydrolyzed hylaline cartilage hHC to have protective effects on cartilage degeneration in a mouse model of PTOA. Some of this data waspresented in our technical report last year, and it is now developed adequately to be in an under development manuscript to be submittedthis fall Fall 2021. Despite residual institutional shutdowns caused by the COVID-19 pandemic, significant progress has been made on thefirst two objectives of this project, with progress expected to continue apace on all objectives.


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  • Medicine and Medical Research

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[A, Approved For Public Release]