Accession Number:

AD1158214

Title:

Multimodal Intervention Trial for Cognitive Deficits in Neurofibromatosis Type 1: Efficacy of Computerized Cognitive Training and Stimulant Medication

Descriptive Note:

[Technical Report, Final Report]

Corporate Author:

CHILDRENS NATIONAL MEDICAL CTR WASHINGTON DC

Personal Author(s):

Report Date:

2021-12-01

Pagination or Media Count:

14

Abstract:

Children with NF1 demonstrate working memory difficulties which impacts cognitive and academic functioning. One hundred and three children with NF1, age 8-16 years M 11.37 years, SD 2.21 at four participating sites 50.5 percent Male, 78.6 percent Not HispanicLatino, 68.0 percent White, 14.6 percent on stimulant medication, were screened using a battery of neurocognitive tests and parent-completed questionnaires. The intervention phase included 82 children who were stratified by stimulant medication use and randomized equally between two interventions CogmedRM n 41, or the active control, MobyMax, an online reading program n 41. Children who completed CogmedRM did not outperform children who completed MobyMax but demonstrated improvement on digit span backward and spatial span forward. This computerized, home-based working memory training program was acceptable, feasible, and enjoyable for children and adolescents with NF1.

Descriptors:

Subject Categories:

  • Medicine and Medical Research
  • Genetic Engineering and Molecular Biology
  • Psychology

Distribution Statement:

[A, Approved For Public Release]