Targeting Diet-Microbiome Interactions in the Pathogenesis of Parkinson's Disease
[Technical Report, Annual Report]
CALIFORNIA INST OF TECH PASADENA
Pagination or Media Count:
The current project will analyze the gut microbiome and metabolites from PD patients and controls, and employ clinically relevant mouse models to determine how metabolites produced by the microbiome from dietary substrates affect motor symptoms. We propose to test whether directly regulating microbial metabolite profiles using designer dietary fibers and probiotics offers new avenues for ameliorating PD-like symptoms.
- Medicine and Medical Research