Accession Number:

AD1158148

Title:

Targeting Diet-Microbiome Interactions in the Pathogenesis of Parkinson's Disease

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

CALIFORNIA INST OF TECH PASADENA

Personal Author(s):

Report Date:

2021-10-01

Pagination or Media Count:

10

Abstract:

The current project will analyze the gut microbiome and metabolites from PD patients and controls, and employ clinically relevant mouse models to determine how metabolites produced by the microbiome from dietary substrates affect motor symptoms. We propose to test whether directly regulating microbial metabolite profiles using designer dietary fibers and probiotics offers new avenues for ameliorating PD-like symptoms.

Descriptors:

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]