Accession Number:



Prazosin for Prophylaxis of Chronic Post-Traumatic Headaches in OEF/OIF/OND Service Members and Veterans with Mild TBI

Descriptive Note:

[Technical Report, Annual Report]

Corporate Author:

Seattle Institute for Biomedical and Clinical Research

Personal Author(s):

Report Date:


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Headaches following combat-related mild traumatic brain injury mTBI are common, can be refractory to standard therapies, and may persist and worsen to become a debilitating chronic pain syndrome. The purpose of the proposed study is to evaluate the centrally acting alpha-1 adrenoreceptor antagonist drug prazosin as a prophylactic treatment for chronic posttraumatic headache. The impetus for this study comes from a large open-label case series in Iraq and Afghanistan Veterans with mTBI and posttraumatic headaches and data from a placebo-controlled trial evaluating use of prazosin for PTSD in Iraq and Afghanistan active-duty Service Members that found beneficial effect of prazosin for decreasing the frequency and severity of headaches, in addition to decreasing PTSD-related symptoms and improving the quality of sleep. The objectives of this study will be accomplished by conducting a randomized placebo-controlled double blind trial of prazosin vs placebo in 160 IraqAfghanistan active-duty Service Members and Veterans with persistent PTHAs.


Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

[A, Approved For Public Release]