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The Impact of Germline Predisposition to Myelodysplastic Syndrome on Allogeneic Hematopoietic Stem Cell Transplant Outcomes Using Related Donors

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[Technical Report, Annual Report]

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We will use samples from the Center for International Blood and Marrow Transplant Research CIBMTR to determine the frequency with which germline mutations occur in myelodysplastic syndrome MDS patients across the entire age spectrum. In addition to determining mutation frequency, we will associate the germline status of both matched-donor and recipient with engraftment kinetics and post-transplant outcomes. This comprehensive study will change the diagnostic and hematopoietic stem cell transplantation HSCT planning work-up for MDS patients by identifying age groups that are most likely to have a germline predisposition mutation, which will position the HSCT field to implement appropriate clinical testing strategies across the world to detect these types of mutations in MDS patients. This work will also shape HSCT policies regarding allogeneic stem cell donor choices and transplantation protocols for these patients with the goal of improving outcomes.

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  • Medicine and Medical Research

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[A, Approved For Public Release]