Metabolomics: A Window for Understanding Long-Term Physical Consequences of Disturbed Sleep and Hypothalamic-Pituitary-Adrenal Function in Posttraumatic Stress
[Technical Report, Final Report]
NORTHERN CALIFORNIA INST FOR RESEARCH AND EDUCATION SAN FRANCISCO
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Post-traumatic stress PTS is a common psychiatric condition that may result after combat exposure and can have a profound effect on sleep and physical health conditions, such as metabolic syndrome. Sleep disturbances may lead to alterations in stress response hormones of the hypothalamic-pituitary-adrenal HPA axis that may increase metabolic risk. Women may be at particularly high risk for these health concerns, given an increased prevalence of PTS and metabolic conditions in women compared to men. The purpose of this study is to identify biological mechanisms using a broad-based study of metabolomics that may explain differences in PTS, sleep disturbances, and metabolic risk in men and women. This broad approach can reveal circulating small molecules that affect cell and physiological function and will be used to identify biochemical pathways involved in PTS, sleep disturbances, and health. Metabolomic analysis will be performed on precollected plasma samples from a study that had a two-group cross-sectional design in which main comparisons were with medically healthy medication-free male and pre-menopausal female subjects with chronic PTS N 44 and trauma-exposed, age-matched controls N 44. Previously collected measures, including sleep EEG and metabolic markers e.g., fasting glucose, insulin response to oral glucose tolerance test OGTT, fasting lipids, and leptin, will also be examined.
- Medicine and Medical Research