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Modeling Lupus Nephritis in a Human Kidney Microphysiological System

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[Technical Report, Annual Report]

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University of Washington, Office of Sponsored Programs

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The kidney is highly susceptible to injury from many systemic inflammatory and autoimmune diseases, including systemic lupus erythematosus SLE, which is one of the FY19 CDMRP Topic Area. Among people with SLE, kidney involvement lupus nephritis affects 60 -80 of SLE patients and is recognized as a main contributor to morbidity and mortality. End stage renal disease occurs in 25 of SLE patients within 15 years of onset, even with modern day immunosuppressive treatment. We have developed a three-dimensional flow directed kidney-on-a-chip populated with human kidney cells, with functional characterization of key component structures of the kidney cortical tubulo-interstitium. In Year 1, we have focused on Aim 1, major task 1 and major task 2. Our overall goal is to use these pre-clinical studies to discover more effective strategies for treating and curing individual patients with SLE, so that clinical studies can then be conducted to improve their quality and quantity of life.

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[A, Approved For Public Release]