Accession Number:

AD1147754

Title:

Comparative Computational Modeling of Immune Responses to Vaccines

Descriptive Note:

[Technical Report, Final Report]

Corporate Author:

ioGenetics LLCVersiti Inc.

Report Date:

2021-06-21

Pagination or Media Count:

819

Abstract:

The project assessed the ability of a computational immunology platform as a predictor of multifaceted immune responses in humans and mice. An accurate computational predictor of immune responses in individuals of differing immunogenetics potentially enable the rapid development of vaccines for emerging pathogens with more confidence than depending on animal models, which do not always replicate human disease, nor the immune responses of a diverse human population. The project mapped epitopes in ten FDA approved vaccines and in SARS-CoV-2. B and T cell responses to SARS-CoV-2 were evaluated in convalescent human volunteers in comparison to computational predictions.

Descriptors:

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

[A, Approved For Public Release]